Organic Chemistry

Download The Epothilones: An Outstanding Family of Anti-Tumor Agents: by Johann H. Mulzer,Karl-Heinz Altmann,Gerhard Höfle,Rolf PDF

By Johann H. Mulzer,Karl-Heinz Altmann,Gerhard Höfle,Rolf Müller,Kathrin Prantz

Epothilones have got strange consciousness during the last ten years. they're novel antitumor medications which a great deal like their predecessor paclitaxel (Taxol) act through microtubule stabilization. compared to paclitaxel and a couple of replacement medicines with an identical mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have major merits, in particular very excessive job within the nanomolar diversity and coffee susceptibility in the direction of multidrug resistance. Epothilone B and several other derivatives thereof are in section I-III scientific trials; one in every of them (ixabepilone, BMS) is already out there, others are meant to look out there within the close to destiny. All evidently happening epothilones were remoted from Sorangium cellulosum; their antitumor motion is traced again to the stabilization of microtubules. as a result, the formation of the mitototic spindle is unlawful and the cellphone undergoes apoptosis.

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