Organic Chemistry

Download Organic Chemistry of Drug Degradation (Drug Discovery) by Min Li PDF

By Min Li

the majority of medications are natural molecular entities. a transparent knowing of the natural chemistry of drug degradation is key to conserving the steadiness, efficacy, and security of a drug product all through its shelf-life. in the course of analytical technique improvement, balance checking out, and pharmaceutical production troubleshooting actions, one of many usually taking place and typically difficult occasions will be the identity of drug degradants and figuring out of drug degradation mechanisms and pathways. This e-book is written via a veteran of the pharmaceutical who has first-hand adventure in drug layout and improvement, drug degradation mechanism stories, analytical improvement, and production method troubleshooting and development. the writer discusses numerous degradation pathways with an emphasis at the mechanisms of the underlying natural chemistry, which should still relief enormously within the efforts of degradant identity, formula improvement, analytical improvement, and production procedure development. natural reactions which are major in drug degradation will first be reviewed after which illustrated by way of examples of drug degradation pronounced within the literature. the writer brings the publication to an in depth with a last bankruptcy devoted to the tactic for speedy elucidation of drug degradants with reference to the present regulatory requisites and guidance. One bankruptcy that are meant to receive detailed awareness is bankruptcy three, Oxidative Degradation. Oxidative degradation is without doubt one of the most typical degradation pathways yet maybe the main advanced one. This bankruptcy employs greater than sixty drug degradation case experiences with in-depth dialogue in regard to their distinctive degradation pathways. With the expanding regulatory specifications at the caliber and defense of pharmaceutical items, specifically with reference to drug impurities and degradants, the booklet could be a useful source for pharmaceutical and analytical scientists who interact in formula improvement, analytical improvement, balance stories, degradant id, and aid of producing approach development. furthermore, it's going to even be priceless to scientists engaged in drug discovery and improvement in addition to in drug metabolism studies.

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