By Francois Terrier
This e-book offers a finished review of nucleophilic fragrant substitutions, targeting the mechanistic and artificial good points that govern those reactions.
The first bankruptcy provides a close mechanistic research of the standards deciding on the feasibility of SNAr substitutions, offering decisive info to foretell regioselectivity of many reactions and to outline the stipulations for concerted SNAr methods. Reflecting the most important function performed via those species as intermediates in such a lot SNAr reactions, bankruptcy 2 then discusses the chemistry of anionic sigma-complexes. bankruptcy three describes the concept that of superelectrophilicity in SNAr substitutions, because it has lately emerged from the reactivity of strongly electron-deficient fragrant and heteroaromatic buildings. the various man made functions are thought of extensive within the chapters four and five that stick with on intermolecular and intramolecular nucleophilic fragrant substitutions. Then, bankruptcy 6 makes a speciality of substitutions continuing officially via displacement of a hydride ion, a sizzling subject within the box. the ultimate bankruptcy brings jointly concise but entire discussions surrounding SNAr photosubstitutions, radical substitutions, and ANRORC substitutions.
Authored through a hugely revered chemist who has contributed drastically to the sector during the last twenty years, this can be a invaluable details resource for all natural chemists operating in academia or the pharmaceutical and agrochemical industries.
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